Lamotrigine add-on for drug-resistant partial epilepsy

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LAMOTRIGINE AS ADD-ON THERAPY IN CHILDREN WITH DRUG-RESISTANT EPILEPSY (IRANIAN EXPERIENCE)

Lamotrigine (LTG), a newly developed antiepileptic drug (AED), is efficacious in treating refractory epilepsy. This study was designed to evaluate the efficacy and safety of LTG as add-on therapy in 40 children with refractory epilepsy. The trial was an open-labeled prospective study in children with drug-resistant epilepsy aged

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Tiagabine add-on for drug-resistant partial epilepsy.

BACKGROUND Epilepsy is a common neurological condition that affects almost 0.5% to 1% of the population. Nearly 30% of people with epilepsy are resistant to currently available drugs. Tiagabine is one of the newer antiepileptic drugs; its effects as an adjunct (add-on) to standard drugs are assessed in this review. OBJECTIVES To evaluate the effects of add-on treatment with tiagabine on seizu...

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lamotrigine as add-on therapy in children with drug-resistant epilepsy (iranian experience)

lamotrigine (ltg), a newly developed antiepileptic drug (aed), is efficacious in treating refractory epilepsy. this study was designed to evaluate the efficacy and safety of ltg as add-on therapy in 40 children with refractory epilepsy. the trial was an open-labeled prospective study in children with drug-resistant epilepsy aged <14 years, who had at least 4 seizures per month in spite of recei...

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Lamotrigine treatment in childhood drug resistant epilepsy.

The clinical response to lamotrigine has been evaluated in a group of 63 drug resistant epileptic children in an open add-on trial. A negative response was observed in 30 subjects. In 11 patients, after an initial improvement lasting a mean period of 8 months, seizures recurred with the same frequency present before the beginning of the treatment. Twenty-two patients responded to lamotrigine tr...

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Long-term open multicentre, add-on trial of vigabatrin in adult resistant partial epilepsy

Vigabatrin (VGB) has been shown in a number of clinical trials with varying designs to be effective and well-tolerated as both add-on therapy and monotherapy in epilepsy with partial seizures with or without secondary generalization as well as in infantile spasms. The present study is an open, long-term (1 year) extension of a randomized double-blind placebo-controlled multicentre Canadian tria...

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ژورنال

عنوان ژورنال: Cochrane Database of Systematic Reviews

سال: 2016

ISSN: 1465-1858

DOI: 10.1002/14651858.cd001909.pub2